certified writers
chat off
Toll Free:
order now
get your paper now
Get a free quote
Order your paper
Customer login
order now
← Uterus Changes During PregnancyType 2 Diabetes →
Live Chat

ACE Inhibitors in Diabetes

Buy custom ACE Inhibitors in Diabetes essay paper cheap

Diabetes, especially type II diabetes mellitus in adults is commonly associated with arterial hypertension. There are numerous antihypertensive drugs that can be generally prescribed in arterial hypertension: adrenergic receptor antagonists (β-blockers, α-blockers, mixed α, β-blockers), adrenergic receptor agonists (α-2 agonists), angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor antagonists, calcium channel blockers, diuretics, renin inhibitors, vasodilators. However, in diabetes pharmacokinetics as well as pharmacodynamics of any drug may follow an altered pathway that precludes or transforms their wide application in treating concomitant arterial hypertension and cardiovascular disorders. For example, the 2007 Guidelines for the Management of Arterial Hypertension (Mancia et al, 2007) states:

β-blockers and thiazide diuretics should not be preferred as the first step drugs because they may worsen insulin resistance and lead to increased doses or numbers of antidiabetic agents.

In diabetes, management of concomitant diseases is of paramount importance. As soon as cardiovascular abnormalities (like arterial hypertension or congestive heart failure) are adequately medicated, the quality of life and the expectant life duration improve substantially. In combination with tight glycemic control, this approach benefits most. The Institute for Clinical Systems Improvement emphasizes (Riethof et al, 2012): “A randomized controlled trial has shown a 50% reduction in major cardiovascular events through a multifactorial intervention targeting hyperglycemia, hypertension, dyslipidemia, microalbuminuria, aspirin and ACE inhibitor use in individuals with microalbuminuria”.

ACE blockers have shown clear benefits in arterial hypertension management in diabetes mellitus. These agents not only control blood pressure safely enough to be recommended (Mancia et al, 2007), but also show advantages in randomized controlled trials. In the Table 1, the evidence-based conclusions on ACE inhibitors in diabetes and arterial hypertension are shown.

Table 1. Evidence for ACE inhibitors in diabetes mellitus type II.


Study description


Yususf et al, 2000

More than 3,000 patients aged > 55 y with diabetes and cardiovascular events were assigned placebo or ACE inhibitor

4.5 y follow up

Ramipril showed benefits for cardiovascular events that were greater than that attributable to the decrease in blood pressure

Wing et al, 2003

More than 6,000  mean age 72 y

4.1 y follow up

ACE inhibitors when compared to diuretics showed better outcomes and less death rate

ACE inhibitors are among the first line remedies in treating arterial hypertension in diabetes type II. They are especially indicated when microalbuminuria develops since these agents show clear renoprotective features, they increase the body’s sensitivity to insulin, they also have protective qualities for the heart, eye and peripheral nerve function. All these attribute to the modern evidence based clinical implications of the ACE inhibitors in diabetes type II in adults.

Buy custom ACE Inhibitors in Diabetes essay paper cheap

Order Now

Related essays

  1. Type 2 Diabetes
  2. Statistical Data of Congenital Heart Disease
  3. Uterus Changes During Pregnancy
why we are #1
years of experience in
the writing industry
grateful regular customers
a full spectrum of services
timely delivery
100% guarantee of total privacy
experienced specialists in writing
original writing only
free-of-charge revision within 2 days
direct communication with your personal writer
free cover and reference page
current status
8 chat/phone agents online right now
763 specialists functioning
18454 writers in our base
8 new specialists passed test this week
10582 written pages
3307340 written words
8.5 out of 10 actual average quality score
Contented clients: 97%
Type of assignment:
Writer level:
Cost per page: ...
Number of pages:
Total without discount: ...
Academic Help
Good Writing Assistance
Student's Life
Using Writing Service
Writing Help
Writing Service
Writing Term Paper
How Reading Assists in Writing Academic Papers of Any Complexity
Cheating Guide for Students
Tips to Avoid Common Writing Mistakes
What Are the Consequences of Steroid Use in Sports?
How to Be Able to Read Art Painting

15% off your first custom essay order. Order now

from $11.99/PAGE